Guide Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use

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The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples.

Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs.

The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. Drugs to Kill Germs 3. Cardiovascular Drugs, From Nitroglycerin to Lipitor 4. Joseph's College , Philadelphia , in Kende at the University of Rochester.

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Roth has held a number of positions in his career, from "Scientist" medicinal chemist through to vice president-level positions in drug discovery, and his accomplishments in his career include the discovery of the molecule atorvastatin , which would become the drug Lipitor. In , year-old Roth began work as a medicinal chemist for the Parke Davis research area of Warner-Lambert, [2] [3] becoming the chemistry co-chair of the statins effort, with biologist Roger Newton, in Before atorvastatin, Roth worked to develop a different drug, but Sandoz AG beat his team to a patent.

Roth was listed as the inventor of trans [2- 3- or 4-carboxamido-substituted pyrrolyl alkyl]hydroxypyranone, patented in , and developed into the on-market drug, atorvastatin, which ultimately would be sold as Lipitor, [2] [8] [9] [10] and which would become the largest-selling drug in pharmaceutical history by From until , Roth served as an adjunct professor in the Department of Medicinal Chemistry at the University of Michigan.


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According to the Chemical Heritage Foundation , in "addition to his discovery of atorvastatin, Roth is the inventor or co-inventor of 42 patents and the author or co-author of 48 manuscripts, 35 published abstracts and eight book chapters. The following are good sources from which further information on the article's subject may be found, that may be of interest to readers and article editors.

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It includes sources not yet cited, and sources whose content may yet provide further insights into the subject. From Wikipedia, the free encyclopedia. This section needs expansion with: sourced DOB, middle name, and other sourced information on early life. You can help by adding to it.

Table of contents for Laughing gas, viagra, and lipitor

February This section may need to be rewritten to comply with Wikipedia's quality standards , as the format of the citations, while adequate, and academic, is not standard for wikipedia, in particular lacking links and being inconsistent in format with rest of article sources. You can help. The discussion page may contain suggestions.

How Viagra Was Discovered: Accidental Drugs

Retrieved 2 February Fortune January Here's how Pfizer did it. The Wall Street Journal January